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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SLC6A4
All Species:
10
Human Site:
S40
Identified Species:
20
UniProt:
P31645
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P31645
NP_001036.1
630
70325
S40
T
P
G
D
K
V
E
S
G
Q
I
S
N
G
Y
Chimpanzee
Pan troglodytes
XP_001135066
630
70262
S40
T
P
G
D
K
V
E
S
G
Q
I
S
N
G
Y
Rhesus Macaque
Macaca mulatta
Q9MYX0
630
70239
S40
T
P
G
D
K
V
E
S
G
Q
I
S
N
G
Y
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q60857
630
70129
P40
T
P
A
D
K
A
E
P
G
Q
I
S
N
G
Y
Rat
Rattus norvegicus
P31652
630
70153
P40
T
T
A
D
R
A
E
P
S
Q
I
S
N
G
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508462
865
94609
G270
G
G
A
G
P
G
L
G
P
P
P
P
G
R
K
Chicken
Gallus gallus
NP_998737
670
74409
M80
S
S
G
P
C
S
G
M
G
E
A
E
D
A
Q
Frog
Xenopus laevis
A7Y2W8
633
71004
Y50
G
N
V
W
R
F
P
Y
L
C
Y
R
N
G
G
Zebra Danio
Brachydanio rerio
NP_001035061
646
72103
R53
G
Q
V
S
N
G
Y
R
S
T
S
P
Q
S
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P51905
622
69307
D35
K
E
S
P
N
N
E
D
D
S
N
E
D
D
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q03614
615
69247
P38
V
N
T
E
P
K
D
P
A
R
E
Q
W
S
G
Sea Urchin
Strong. purpuratus
XP_001204030
641
70931
P49
H
V
L
G
F
P
P
P
V
V
N
V
E
A
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
98.5
N.A.
N.A.
92.8
91.7
N.A.
38.1
77.6
42.1
68.5
N.A.
50.4
N.A.
43.6
49.4
Protein Similarity:
100
99.5
99.5
N.A.
N.A.
95.5
94.9
N.A.
52.9
85.2
60.8
80.6
N.A.
66.9
N.A.
63.3
66.6
P-Site Identity:
100
100
100
N.A.
N.A.
80
60
N.A.
0
13.3
13.3
0
N.A.
6.6
N.A.
0
0
P-Site Similarity:
100
100
100
N.A.
N.A.
80
66.6
N.A.
0
33.3
20
0
N.A.
13.3
N.A.
20
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
25
0
0
17
0
0
9
0
9
0
0
17
0
% A
% Cys:
0
0
0
0
9
0
0
0
0
9
0
0
0
0
0
% C
% Asp:
0
0
0
42
0
0
9
9
9
0
0
0
17
9
0
% D
% Glu:
0
9
0
9
0
0
50
0
0
9
9
17
9
0
0
% E
% Phe:
0
0
0
0
9
9
0
0
0
0
0
0
0
0
0
% F
% Gly:
25
9
34
17
0
17
9
9
42
0
0
0
9
50
25
% G
% His:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
42
0
0
0
0
% I
% Lys:
9
0
0
0
34
9
0
0
0
0
0
0
0
0
9
% K
% Leu:
0
0
9
0
0
0
9
0
9
0
0
0
0
0
9
% L
% Met:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% M
% Asn:
0
17
0
0
17
9
0
0
0
0
17
0
50
0
0
% N
% Pro:
0
34
0
17
17
9
17
34
9
9
9
17
0
0
9
% P
% Gln:
0
9
0
0
0
0
0
0
0
42
0
9
9
0
9
% Q
% Arg:
0
0
0
0
17
0
0
9
0
9
0
9
0
9
0
% R
% Ser:
9
9
9
9
0
9
0
25
17
9
9
42
0
17
0
% S
% Thr:
42
9
9
0
0
0
0
0
0
9
0
0
0
0
0
% T
% Val:
9
9
17
0
0
25
0
0
9
9
0
9
0
0
0
% V
% Trp:
0
0
0
9
0
0
0
0
0
0
0
0
9
0
0
% W
% Tyr:
0
0
0
0
0
0
9
9
0
0
9
0
0
0
42
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _